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" width="8" height="8"/> Peripheral neuropathy of feet, Diabetes, statins, genetics, age?
GA Hiker
Aug 20 2014, 05:27 PM
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This past June I began experiencing neuropathy symptoms in the soles of my feet. When I got into bed at night they were mildly tingly and warmish, not strongly so but enough to prevent me from falling asleep. Placing one sole against the opposite, cool calf helped one foot at a time; lying on my back with knees bent and my soles against a cool part of the sheet was good for a short time. But eventually I resorted to my drug of choice -- a shot of Scotch -- to fall asleep. Occasionally, I felt the symptoms during the day as well, usually when I was seated at my computer or watching TV.

I saw a PA in my endo's office. She didn't believe it could be due to my diabetes because my A1c's have always been in the 5.8 to 6.2 range. She had no other idea what the cause could be but said if the symptoms got worse they could prescribe a drug "but they have undesirable side effects." When the symptoms persisted I left a message for my endo and got a response from his "team" recommending a neurologist. I called and scheduled an appointment.

Before the neuro appointment it somehow occurred to me to check out the possible side effects of statins, in particular Zocor, which I have been taking for the last 10 years. Sure enough, neuropathy was on the list. I immediately stopped the Zocor and relief came in a couple of days. I stayed off for 2 weeks and then tried taking the Zocor again. On the second night, the symptoms returned. No more Zocor! I contacted the NP in my cardiologist's office who prescribed Crestor instead, but I held off starting it.

Then I saw the neurologist. He said it was probably my diabetes, that even though my A1c is excellent "there are always people at the end of the curve." "We recommend that people with neuropathy get their A1c's below 7 to improve things but obviously you can't do that." It could be the statin he said, but he didn't sound like he really believed it. And, he said, it could be genetics or just age. "People get neuropathy with no diabetes or other obvious cause." Like my endo's PA, he said that if it got worse there were drugs to treat it. That night, talking with my sister, I learned that one of my cousins and his father, my uncle, had neuropathy (no diabetes).

I have stayed off the Zocor. I started Crestor about 10 days ago. Crestor's possible side effects also include neuropathy. My symptoms have not returned.

I though I should share this experience.

 
JohnG
Aug 20 2014, 08:33 PM
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QUOTE(GA Hiker @ Aug 20 2014, 12:27 PM)
This past June I began experiencing neuropathy symptoms in the soles of my feet. When I got into bed at night they were mildly tingly and warmish, not strongly so but enough to prevent me from falling asleep. Placing one sole against the opposite, cool calf helped one foot at a time; lying on my back with knees bent and my soles against a cool part of the sheet was good for a short time. But eventually I resorted to my drug of choice -- a shot of Scotch -- to fall asleep. Occasionally, I felt the symptoms during the day as well, usually when I was seated at my computer or watching TV.

I saw a PA in my endo's office. She didn't believe it could be due to my diabetes because my A1c's have always been in the 5.8 to 6.2 range. She had no other idea what the cause could be but said if the symptoms got worse they could prescribe a drug "but they have undesirable side effects." When the symptoms persisted I left a message for my endo and got a response from his "team" recommending a neurologist. I called and scheduled an appointment.

Before the neuro appointment it somehow occurred to me to check out the possible side effects of statins, in particular Zocor, which I have been taking for the last 10 years. Sure enough, neuropathy was on the list. I immediately stopped the Zocor and relief came in a couple of days. I stayed off for 2 weeks and then tried taking the Zocor again. On the second night, the symptoms returned. No more Zocor! I contacted the NP in my cardiologist's office who prescribed Crestor instead, but I held off starting it.

Then I saw the neurologist. He said it was probably my diabetes, that even though my A1c is excellent "there are always people at the end of the curve." "We recommend that people with neuropathy get their A1c's below 7 to improve things but obviously you can't do that." It could be the statin he said, but he didn't sound like he really believed it. And, he said, it could be genetics or just age. "People get neuropathy with no diabetes or other obvious cause." Like my endo's PA, he said that if it got worse there were drugs to treat it. That night, talking with my sister, I learned that one of my cousins and his father, my uncle, had neuropathy (no diabetes).

I have stayed off the Zocor. I started Crestor about 10 days ago. Crestor's possible side effects also include neuropathy. My symptoms have not returned.

I though I should share this experience.


I have neuropathy and have always been considered to have low glycemic values....I have not had a A1c above 6 in over 10 years. I also believe I'm at the end of the curve.
My Doctor does clinical study's for all kinds of drugs and testing procedures, he says he has seen many individuals that have had high BG most of their long lives with no
side effects and has also seen many people with some or all the advertised side effects that lived most of their life with close to normal BG.
Note: I also have lower than normal lipids...I still take BP meds, prophylactic for kidney damage, and I'm also showing lower than normal GFR last test was >53 and has been as low as >38.

Poison Ivy, I can handle it, my mother can just walk close to it and breakout in a horrible rash...so we are related and on opposite ends of the curve.
My Mum and Dad do not have Diabetes, neither is over weight, neither needed glasses until there 70's. My brother and I are both skinny, diabetic, insulin dependent,
wear glasses since grammar school, have neuropathy, frozen shoulder, trigger finger, the only positive note is we have strong hearts and no eye damage so far...;-)

 
GA Hiker
Aug 20 2014, 09:14 PM
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QUOTE(JohnG @ Aug 20 2014, 04:33 PM)
I have neuropathy and have always been considered to have low glycemic values....I have not had a A1c above 6 in over 10 years. I also believe I'm at the end of the curve.
My Doctor does clinical study's for all kinds of drugs and testing procedures, he says he has seen many individuals that have had high BG most of their long lives with no
side effects and has also seen many people with some or all the advertised side effects that lived most of their life with close to normal BG.
Note: I also have lower than normal lipids...I still take BP meds, prophylactic for kidney damage, and I'm also showing lower than normal GFR last test was >53 and has been as low as >38.

Poison Ivy, I can handle it, my mother can just walk close to it and breakout in a horrible rash...so we are related and on opposite ends of the curve.
My Mum and Dad do not have Diabetes, neither is over weight, neither needed glasses until there 70's. My brother and I are both skinny, diabetic, insulin dependent,
wear glasses since grammar school, have neuropathy, frozen shoulder, trigger finger, the only positive note is we have strong hearts and no eye damage so far...;-)


I also take BP for kidney protection even though my BP is low without it. My GFRs are sometimes below 60, lowest 53, but have been stable in this range for the last 6 years so the nephrologist thinks they may "always have been that way." I am also not sensitive to poison ivy. Eyes are good!
 
Arlene S.
Aug 20 2014, 11:47 PM
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QUOTE(JohnG @ Aug 20 2014, 04:33 PM)
I have neuropathy and have always been considered to have low glycemic values....I have not had a A1c above 6 in over 10 years. I also believe I'm at the end of the curve.
My Doctor does clinical study's for all kinds of drugs and testing procedures, he says he has seen many individuals that have had high BG most of their long lives with no
side effects and has also seen many people with some or all the advertised side effects that lived most of their life with close to normal BG.
Note: I also have lower than normal lipids...I still take BP meds, prophylactic for kidney damage, and I'm also showing lower than normal GFR last test was >53 and has been as low as >38.

Poison Ivy, I can handle it, my mother can just walk close to it and breakout in a horrible rash...so we are related and on opposite ends of the curve.
My Mum and Dad do not have Diabetes, neither is over weight, neither needed glasses until there 70's. My brother and I are both skinny, diabetic, insulin dependent,
wear glasses since grammar school, have neuropathy, frozen shoulder, trigger finger, the only positive note is we have strong hearts and no eye damage so far...;-)


My podiatrist and other doctors have told me that most people who have had diabetes for 20 plus years have some neuropathy. My podiatrist tests me every time I go for a visit and there is a mild reaction to the filament and one other test. So far I've had no symptoms and my pulses are good so far.
 
GA Hiker
Aug 21 2014, 12:08 AM
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QUOTE(Arlene S. @ Aug 20 2014, 07:47 PM)
My podiatrist and other doctors have told me that most people who have had diabetes for 20 plus years have some neuropathy. My podiatrist tests me every time I go for a visit and there is a mild reaction to the filament and one other test. So far I've had no symptoms and my pulses are good so far.


I was diagnosed 13 years ago but I know that I had it for a year, and maybe several years, before that. All of the tests -- filament, sharp point, reflex, pulse -- are normal.
 
Manxman
Aug 21 2014, 12:33 AM
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QUOTE(GA Hiker @ Aug 20 2014, 10:27 AM)
This past June I began experiencing neuropathy symptoms in the soles of my feet. When I got into bed at night they were mildly tingly and warmish, not strongly so but enough to prevent me from falling asleep. Placing one sole against the opposite, cool calf helped one foot at a time; lying on my back with knees bent and my soles against a cool part of the sheet was good for a short time. But eventually I resorted to my drug of choice -- a shot of Scotch -- to fall asleep. Occasionally, I felt the symptoms during the day as well, usually when I was seated at my computer or watching TV.

I saw a PA in my endo's office. She didn't believe it could be due to my diabetes because my A1c's have always been in the 5.8 to 6.2 range. She had no other idea what the cause could be but said if the symptoms got worse they could prescribe a drug "but they have undesirable side effects." When the symptoms persisted I left a message for my endo and got a response from his "team" recommending a neurologist. I called and scheduled an appointment.

Before the neuro appointment it somehow occurred to me to check out the possible side effects of statins, in particular Zocor, which I have been taking for the last 10 years. Sure enough, neuropathy was on the list. I immediately stopped the Zocor and relief came in a couple of days. I stayed off for 2 weeks and then tried taking the Zocor again. On the second night, the symptoms returned. No more Zocor! I contacted the NP in my cardiologist's office who prescribed Crestor instead, but I held off starting it.

Then I saw the neurologist. He said it was probably my diabetes, that even though my A1c is excellent "there are always people at the end of the curve." "We recommend that people with neuropathy get their A1c's below 7 to improve things but obviously you can't do that." It could be the statin he said, but he didn't sound like he really believed it. And, he said, it could be genetics or just age. "People get neuropathy with no diabetes or other obvious cause." Like my endo's PA, he said that if it got worse there were drugs to treat it. That night, talking with my sister, I learned that one of my cousins and his father, my uncle, had neuropathy (no diabetes).

I have stayed off the Zocor. I started Crestor about 10 days ago. Crestor's possible side effects also include neuropathy. My symptoms have not returned.

I though I should share this experience.


Barbara,

I wish that I could offer some helpful info., but can't. After 63 years of Diabetes, I do not have any neuropathy symptoms. For about 20 of those years, I was also addicted to tobacco so one would think that peripheral circulatory and related nerve problems would certainly affect me. Very happy to say that this is not the case. I hope that you can find easy and effective treatment. I was also on Crestor for about a decade and found it to be much more effective than other statins that I had tried, but stopped it due to high co-pays and now use Atorvastatin with good restuls and no neuropathy.

This post has been edited by Manxman: Aug 21 2014, 12:35 AM
 
Arlene S.
Aug 21 2014, 12:49 AM
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QUOTE(GA Hiker @ Aug 20 2014, 01:27 PM)
This past June I began experiencing neuropathy symptoms in the soles of my feet. When I got into bed at night they were mildly tingly and warmish, not strongly so but enough to prevent me from falling asleep. Placing one sole against the opposite, cool calf helped one foot at a time; lying on my back with knees bent and my soles against a cool part of the sheet was good for a short time. But eventually I resorted to my drug of choice -- a shot of Scotch -- to fall asleep. Occasionally, I felt the symptoms during the day as well, usually when I was seated at my computer or watching TV.

I saw a PA in my endo's office. She didn't believe it could be due to my diabetes because my A1c's have always been in the 5.8 to 6.2 range. She had no other idea what the cause could be but said if the symptoms got worse they could prescribe a drug "but they have undesirable side effects." When the symptoms persisted I left a message for my endo and got a response from his "team" recommending a neurologist. I called and scheduled an appointment.

Before the neuro appointment it somehow occurred to me to check out the possible side effects of statins, in particular Zocor, which I have been taking for the last 10 years. Sure enough, neuropathy was on the list. I immediately stopped the Zocor and relief came in a couple of days. I stayed off for 2 weeks and then tried taking the Zocor again. On the second night, the symptoms returned. No more Zocor! I contacted the NP in my cardiologist's office who prescribed Crestor instead, but I held off starting it.

Then I saw the neurologist. He said it was probably my diabetes, that even though my A1c is excellent "there are always people at the end of the curve." "We recommend that people with neuropathy get their A1c's below 7 to improve things but obviously you can't do that." It could be the statin he said, but he didn't sound like he really believed it. And, he said, it could be genetics or just age. "People get neuropathy with no diabetes or other obvious cause." Like my endo's PA, he said that if it got worse there were drugs to treat it. That night, talking with my sister, I learned that one of my cousins and his father, my uncle, had neuropathy (no diabetes).

I have stayed off the Zocor. I started Crestor about 10 days ago. Crestor's possible side effects also include neuropathy. My symptoms have not returned.

I though I should share this experience.


It's interesting that Zocor could have caused the problem after 10 years. My cardiologist's favorite statin is Crestor but I've been on 10 mg Lipitor (now the generic) for more than 10 years and so far it has been fine.
 
GA Hiker
Aug 21 2014, 02:08 AM
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QUOTE(Arlene S. @ Aug 20 2014, 08:49 PM)
It's interesting that Zocor could have caused the problem after 10 years. My cardiologist's favorite statin is Crestor but I've been on 10 mg Lipitor (now the generic) for more than 10 years and so far it has been fine.


This is not the first problem that Zocor has caused me. Three years ago, shortly before a big birthday, my cholesterol levels rose a bit and my Zocor dose was increased from 20mg to 40 mg. Then, seemed like right after my birthday, every time I sat for a while -- at a meal, a movie, in the car -- when I got up I was so stiff I couldn't stand up straight right away,but after a few steps I was fine. When I saw my endo I commented that I had that birthday and my body really felt older! He suggested that it was the Zocor and he was right! I went back to the 20mg and the stiffness disappeared.
 
Arlene S.
Aug 21 2014, 02:53 AM
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QUOTE(GA Hiker @ Aug 20 2014, 10:08 PM)
This is not the first problem that Zocor has caused me. Three years ago, shortly before a big birthday, my cholesterol levels rose a bit and my Zocor dose was increased from 20mg to 40 mg. Then, seemed like right after my birthday, every time I sat for a while -- at a meal, a movie, in the car -- when I got up I was so stiff I couldn't stand up straight right away,but after a few steps I was fine. When I saw my endo I commented that I had that birthday and my body really felt older! He suggested that it was the Zocor and he was right! I went back to the 20mg and the stiffness disappeared.


At one point after I had been on Lipitor for a while I started having muscle aches and my doctor took me off the drug for a few weeks. I continued to have the aches so she put me back on the Lipitor and eventually the aches went away. In your case it certainly seems like the Zocor is causing the problems. It's not unusual to react to one statin and then do well on another. It's the same with BP meds.
 
Mogar
Aug 21 2014, 01:16 PM
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I have been told by a group of doctors that I can be placed on meds for my feet issue also. However the side effects of these drugs will require me taking other drugs, and these drugs will take others.... I love the chain of drugs that will be required. To avoid this, I was informed to take a mild dose of aspirin to cut the pain, as my symptoms are mild.
 
GA Hiker
Aug 21 2014, 02:25 PM
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QUOTE(Mogar @ Aug 21 2014, 09:16 AM)
I have been told by a group of doctors that I can be placed on meds for my feet issue also. However the side effects of these drugs will require me taking other drugs, and these drugs will take others.... I love the chain of drugs that will be required. To avoid this, I was informed to take a mild dose of aspirin to cut the pain, as my symptoms are mild.


Yep! I've been wondering, if I hadn't discovered the possible statin cause on my own, if the neurologist would have considered it. My endo certainly didn't (This is a different endo than the one who quickly suggested that the increased Zocor dose was causing my previous problem). Then, I might have been put on meds for my neuropathy symptoms, meds for their side effects, ad nauseum!
 
Arlene S.
Aug 21 2014, 03:48 PM
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QUOTE(GA Hiker @ Aug 21 2014, 10:25 AM)
Yep! I've been wondering, if I hadn't discovered the possible statin cause on my own, if the neurologist would have considered it. My endo certainly didn't (This is a different endo than the one who quickly suggested that the increased Zocor dose was causing my previous problem). Then, I might have been put on meds for my neuropathy symptoms, meds for their side effects, ad nauseum!


My podiatrist old me to take an Alpha Lipoic Acid supplement as a neuropathy preventative. I did for a while and I will go back to it. It's an antioxidant and I didn't have side effects from it and there have been studies that showed it does work.
 
GA Hiker
Aug 21 2014, 04:40 PM
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QUOTE(Arlene S. @ Aug 21 2014, 11:48 AM)
My podiatrist old me to take an Alpha Lipoic Acid supplement as a neuropathy preventative. I did for a while and I will go back to it. It's an antioxidant and I didn't have side effects from it and there have been studies that showed it does work.


That's interesting. I will look into it, maybe ask my endo next time I see him. I have never seen a podiatrist. Is there reason to see one without necessity?
 
Marty
Aug 21 2014, 08:09 PM
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I had nearly unbearable neuropathy in my feet about 15 years ago. My endo didn't believe it could be a diabetes complication since my A1c's were below 6 and suggested that a vitamin B deficiency might be the cause because I don't eat much meat. I started taking a vitamin B supplement and the pain went away. I discontinued the supplement (I think I forgot why I was taking it :-) and the pain never returned. I spoke with my CDE about that today when he was checking my feet and he commented that vitamin deficiencies and alcohol abuse were the most common causes of neuropathy. I've lost some sensitivity to vibration in my feet (the "tuning fork test") but, luckily, my pressure sensitivity is still normal.

Interestingly, after I just said my endo never showed any interest in my BGs, he downloaded my Dexcom today. Wouldn't you know it, I'd had a horrible spike after rubbing off my infusion set in my sleep last week that I had to (sheepishly) explain...
 
Arlene S.
Aug 21 2014, 08:17 PM
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QUOTE(GA Hiker @ Aug 21 2014, 12:40 PM)
That's interesting. I will look into it, maybe ask my endo next time I see him. I have never seen a podiatrist. Is there reason to see one without necessity?


I see my podiatrist every three months. I have other foot problems and wear custom orthotics. He checks for neuropathy each time.
 
Arlene S.
Aug 21 2014, 08:27 PM
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QUOTE(Marty @ Aug 21 2014, 04:09 PM)
I had nearly unbearable neuropathy in my feet about 15 years ago. My endo didn't believe it could be a diabetes complication since my A1c's were below 6 and suggested that a vitamin B deficiency might be the cause because I don't eat much meat. I started taking a vitamin B supplement and the pain went away. I discontinued the supplement (I think I forgot why I was taking it :-) and the pain never returned. I spoke with my CDE about that today when he was checking my feet and he commented that vitamin deficiencies and alcohol abuse were the most common causes of neuropathy. I've lost some sensitivity to vibration in my feet (the "tuning fork test") but, luckily, my pressure sensitivity is still normal.

Interestingly, after I just said my endo never showed any interest in my BGs, he downloaded my Dexcom today. Wouldn't you know it, I'd had a horrible spike after rubbing off my infusion set in my sleep last week that I had to (sheepishly) explain...


I have lost some vibration sensitivity in one spot but my pressure sensitivity is also still normal. Pulses and reflexes are good so far, even in the ankle with a ton of hardware.

I haven't been to my endo since I started on the Dex and t:slim. I guess I'm going to have to dig out the old netbook so I can upload my Dexcom data. Maybe the t:slim data will be enough.
 
Manxman
Aug 27 2014, 06:24 PM
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Here is some info. on Neuropathy treatment that I received recently- sounds interesting. If/when I suffer from the condition, I would certainly try the vegan diet approach due to the claimed high success rate.

http://www.diabetesselfmanagement.com/blog...hy-pain/?ref=ls
 
GA Hiker
Aug 28 2014, 12:07 AM
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QUOTE(Manxman @ Aug 27 2014, 02:24 PM)
Here is some info. on Neuropathy treatment that I received recently- sounds interesting. If/when I suffer from the condition, I would certainly try the vegan diet approach due to the claimed high success rate.

http://www.diabetesselfmanagement.com/blog...hy-pain/?ref=ls


That is quite interesting! I'd try it too.
 

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